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Assessment of new illicit drugs in sewage and surface waters using UHPLC.QqTOF-MS

AuthorsCampo, Julián ; Andrés-Costa, María Jesús; Andreu Pérez, V. ; Picó, Yolanda
Issue Date1-Oct-2014
Citation14as Jornadas de Análisis Instrumental (2014)
AbstractInsufficiently treated municipal wastewater discharge is identified as the route responsible for surface water contamination by compounds of anthropic origin [1 J. This situation could bring about potential risks for human health and ecosystems. The aim of this study is to optimize a methodology for the simultaneous extraction, determination and quantification of 16 of new illicit to establish the consumption pattern and their environmental impact by analyzing them at the influent and effluent of wastewater treatment plants (WWTPs) and in surface water samples. The applicability and efficiency of the LC-OQTOF-MS technique in automated IDA-MS/MS for the qualitative and quantitative analysis has been demonstrated by the development of one of the first applications reported of this technique for !he simultaneous detem1ination of 16 emerging illicit drugs in wastewater and liver water samples. The selected illicit drugs were ephedrine (EPH), mephedrone (MEP), Methylone (METONE), N Methyl 1¿(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), Dibutylone (bk-MMBDB), 4-Bromo-2,5-Dimethoxyphenethylamine (2C-B), Naphyrone (NAPH), methylenedioxypyrovalerone (MDPV), Ibufotenine (BUF), 1-(3-clorophenil)piperazine (mCPP), 1-(3-triftuorornethylphenyl)piperazine (TFMPP), ¿-pyrrolidinopropiophenone (PPP), ¿-pyrrolidinopentiophenone (alpha-PVP). 4-methyl-¿- pyrrolidinohexaphenone (4'-MePHP), 4-methyl-¿-pyrrolidinobutiophenone (MPBP) and 4-methoxyphencyclidine (4-MeO-PCP). Compounds were isolated and concentrated from water samples using solid phase extraction (SPE) using Strata-X cartridges (200 mg) and methanol. The recoveries for these compounds ranged from 44.7 to 95.9 % and the method detection limits ranged from 0.01 to 1.54 ng L-1. The determination of these compounds in the influent of the selected WWTPs shows the presence of stimulant drugs as EPH in 9.5% at concentration up to 13.4 ng L-1. Hallucinogenic drugs as BUF and 4-MeO-PCP (at concentrations up to 334 and 240 ng L-1, respectively) were detected in 100% and 19% of the influents, respectively. The effluent samples analyzed show that all compounds were completely removed except EPH. These new illicit drugs were detected also al 7 sampling points of the Tuna River Basin al concentrations ranging from 3.84 to 66.8 ng L-1 for BUF and 37.6 ng L-1 for 4-MeO-PCP
DescriptionPóster presentado en 14as Jornadas de Análisis Instrumental, celebrado en Barcelona, España, del 1 al 3 de octubre de 2014
Appears in Collections:(CIDE) Comunicaciones congresos
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