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dc.contributor.author | Sequeira-Mendes, Joana | - |
dc.contributor.author | Gutiérrez Armenta, Crisanto | - |
dc.date.accessioned | 2016-10-28T10:45:42Z | - |
dc.date.available | 2016-10-28T10:45:42Z | - |
dc.date.issued | 2015-07-25 | - |
dc.identifier | doi: 10.1111/tpj.12847 | - |
dc.identifier | issn: 1365-313X | - |
dc.identifier.citation | Plant Journal 83: 38- 51 (2015) | - |
dc.identifier.uri | http://hdl.handle.net/10261/139578 | - |
dc.description.abstract | © 2015 The Authors. Post-embryonic organogenesis in plants requires the continuous production of cells in the organ primordia, their expansion and a coordinated exit to differentiation. Genome replication is one of the most important processes that occur during the cell cycle, as the maintenance of genomic integrity is of primary relevance for development. As it is chromatin that must be duplicated, a strict coordination occurs between DNA replication, the deposition of new histones, and the introduction of histone modifications and variants. In turn, the chromatin landscape affects several stages during genome replication. Thus, chromatin accessibility is crucial for the initial stages and to specify the location of DNA replication origins with different chromatin signatures. The chromatin landscape also determines the timing of activation during the S phase. Genome replication must occur fully, but only once during each cell cycle. The re-replication avoidance mechanisms rely primarily on restricting the availability of certain replication factors; however, the presence of specific histone modifications are also revealed as contributing to the mechanisms that avoid re-replication, in particular for heterochromatin replication. We provide here an update of genome replication mostly focused on data from Arabidopsis, and the advances that genomic approaches are likely to provide in the coming years. The data available, both in plants and animals, point to the relevance of the chromatin landscape in genome replication, and require a critical evaluation of the existing views about the nature of replication origins, the mechanisms of origin specification and the relevance of epigenetic modifications for genome replication. Significance Statement The chromatin lanscape has a direct impact on genome replication at various levels including specification of replication origins, replication timing and the maintenance of genome integrity. | - |
dc.description.sponsorship | MINECO and by an institutional grant from Fundación Ramón Areces to the Centro de Biologia Molecular Severo Ochoa. | - |
dc.publisher | Blackwell Publishing | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | epigenetics | - |
dc.subject | plant | - |
dc.subject | Arabidopsis thaliana | - |
dc.subject | Chromatin | - |
dc.subject | DNA replication | - |
dc.title | Links between genome replication and chromatin landscapes | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1111/tpj.12847 | - |
dc.date.updated | 2016-10-28T10:45:43Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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Gutierrez Crisanto Links between.pdf | 200,59 kB | Adobe PDF | Visualizar/Abrir |
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