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Insights into the determination of the templating nucleotide at the initiation of φ29 DNA replication

AuthorsPrado, Alicia del ; Lázaro, José M. ; Longás, Elisa ; Villar, Laurentino ; Vega, Miguel de ; Salas, Margarita
Issue Date2015
PublisherAmerican Society for Biochemistry and Molecular Biology
CitationJournal of Biological Chemistry 290: 27138- 27145 (2015)
AbstractBackground: The initiation of replication in φ29 mainly occurs opposite the 3' penultimate nucleotide of the template. Results: Mutations in the TP residue Phe-230 changed the specificity for the templating nucleotide. Conclusion: The results suggest a role for Phe-230 in determining the templating nucleotide. Significance: The results shed light on the positioning of the template nucleotide in organisms that initiate with proteinpriming mechanism.
Identifiersdoi: 10.1074/jbc.M115.682278
issn: 1083-351X
Appears in Collections:(CBM) Artículos
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