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Título

Carotenoids exclusively synthesized in red pepper (capsanthin and capsorubin) protect human dermal fibroblasts against UVB induced DNA damage†

AutorFernández-García, Elisabet; Carvajal-Lérida, Irene ; Pérez Gálvez, Antonio
Palabras claveFibroblasts
Carotenoids
Capsanthin
Capsorubin
UVB light
DNA damage
Fecha de publicación18-ago-2016
EditorRoyal Society of Chemistry (Great Britain)
CitaciónPhotochemical and Photobiological Sciences 15: 1204-1211 (2016)
ResumenPhotoprotection by dietary carotenoids has been linked to their antioxidant properties, in particular quenching of singlet molecular oxygen and scavenging of peroxyl radicals. Here, we compared the DNA-protection and antioxidant effects of selected carotenoids exclusively synthesized in red pepper (capsanthin and capsorubin) to the xanthophyll lutein. Preincubation of human dermal fibroblasts (hdf) with capsanthin and capsorubin significantly counteracted UVB induced cytotoxicity at doses between 0 and 300 mJ cm−2. Pretreatment of hdf with capsanthin, capsorubin or lutein (1 μM) significantly decreased the formation of DNA strand breaks following irradiation with UVB light. All carotenoids studied decreased caspase-3 cleavage (a marker for UVB-induced apoptosis), however, caspase dependent PARP-1 cleavage was not affected suggesting that the remaining caspase activity is sufficient to promote UVB-induced apoptosis. It is conceivable that carotenoids selectively interfere with cellular responses activated by UVB-mediated damage. Our findings indicate that capsanthin and capsorubin exhibit similar properties to lutein and could be used as a dietary supplement to improve natural photoprotection.
Descripción29 Páginas; 5 Figuras
Versión del editorhttp://dx.doi.org/10.1039/C6PP00134C
URIhttp://hdl.handle.net/10261/137950
DOI10.1039/C6PP00134C
ISSN1474-905X
E-ISSN1474-9092
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