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Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis

AuthorsFaus, Isabel; Zabalza, Ana; Santiago, Julia ; Nebauer, Sergio G.; Royuela, Mercedes; Serrano, Ramón ; Gadea Vacas, José
Issue Date21-Jan-2015
PublisherBioMed Central
CitationBMC Plant Biology 15: 14 (2015)
Abstract[Background] The increased selection pressure of the herbicide glyphosate has played a role in the evolution of glyphosate-resistance in weedy species, an issue that is becoming a threat to global agriculture. The molecular components involved in the cellular toxicity response to this herbicide at the expression level are still unidentified. [Results] In this study, we identify the protein kinase GCN2 as a cellular component that fosters the action of glyphosate in the model plant Arabidopsis thaliana. Comparative studies using wild-type and gcn2 knock-out mutant seedlings show that the molecular programme that the plant deploys after the treatment with the herbicide, is compromised in gcn2. Moreover, gcn2 adult plants show a lower inhibition of photosynthesis, and both seedlings and adult gcn2 plants accumulate less shikimic acid than wild-type after treatment with glyphosate. [Conclusions] These results points to an unknown GCN2-dependent factor involved in the cascade of events triggered by glyphosate in plants. Data suggest either that the herbicide does not equally reach the target-enzyme in a gcn2 background, or that a decreased flux in the shikimate pathway in a gcn2 plants minimize the impact of enzyme inhibition. © 2015 Faus et al.; licensee BioMed Central.
Publisher version (URL)http://dx.doi.org/10.1186/s12870-014-0378-0
Identifiersissn: 1471-2229
Appears in Collections:(IBMCP) Artículos
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