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Título

Olive oil, compared to a saturated dietary fat, has a protective role on atherosclerosis in niacin-treated mice with metabolic syndrome

AutorMontserrat-de la Paz, Sergio ; Naranjo, María C.; López, Sergio ; Abia, Rocío ; Muriana, Francisco J. G. ; Bermúdez, Beatriz
Palabras claveMonounsaturated fatty acids
Niacin
Monocytes
Atherosclerosis
Macrophages
Metabolic syndrome
Fecha de publicaciónoct-2016
EditorElsevier
CitaciónJournal of Functional Foods 26: 557-564 (2016)
ResumenWe aimed to investigate the impact of high-fat low-cholesterol diets rich in saturated fatty acids (HFLCD-SFAs), monounsaturated FAs (HFLCD-MUFAs) or MUFAs + omega-3 long-chain polyunsaturated FAs (HFLCD-PUFAs) in combination with niacin (NA) on atherosclerotic plaque characteristics in a mouse model (Lepob/obLDLR−/−) of metabolic syndrome (MetS). Compared to a low-fat low-cholesterol diet (LFLCD), HFLCDs increased body weight, triglycerides, insulin, pro-inflammatory cytokines, and circulating monocytes, contributing the HFLCD-SFAs to a predominance of a classical pro-inflammatory Ly6Chi population, whereas HFLCD-MUFAs and HFLCD-PUFAs to a non-classical patrolling Ly6Clo population. HFLCDs promoted atherosclerosis in the aortic roots of animals but the plaque size, collagen, and macrophage content were higher with the HFLCD-SFAs than with the HFLCD-MUFAs or HFLCD-PUFAs. Furthermore, HFLCD-SFAs promoted the intra-plaque accumulation of M1 macrophages, whereas HFLCD-MUFAs and HFLCD-PUFAs favoured the accumulation of M2 macrophages. These data suggest that dietary MUFAs had advantage over SFAs to prevent atherosclerotic events in the NA-treated MetS.
Descripción29 Páginas, 2 tablas, 4 figuras
Versión del editorhttp://dx.doi.org/10.1016/j.jff.2016.08.028
URIhttp://hdl.handle.net/10261/137503
DOI10.1016/j.jff.2016.08.028
ISSN1756-4646
E-ISSN2214-9414
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