English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/137423
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis

AuthorsNieto-Torres, José Luis; Verdiá-Báguena, Carmina; Castaño-Rodríguez, Carlos; Aguilella, Vicente M.; Enjuanes Sánchez, Luis
KeywordsViroporins
Virus
Ion channel
Protein-lipid pore
Replication
Pathogenesis
Inflammasome
Issue Date3-Jul-2015
PublisherMultidisciplinary Digital Publishing Institute
CitationViruses 7(7): 3552-3573 (2015)
AbstractModification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular membranes and self-assemble forming ion conductive pores. In general, these channels display mild ion selectivity, and, eventually, membrane lipids play key structural and functional roles in the pore. Viroporins stimulate virus production through different mechanisms, and ion channel conductivity has been proved particularly relevant in several cases. Key stages of the viral cycle such as virus uncoating, transport and maturation are ion-influenced processes in many viral species. Besides boosting virus propagation, viroporins have also been associated with pathogenesis. Linking pathogenesis either to the ion conductivity or to other functions of viroporins has been elusive for a long time. This article summarizes novel pathways leading to disease stimulated by viroporin ion conduction, such as inflammasome driven immunopathology.
Publisher version (URL)http://dx.doi.org/10.3390/v7072786
URIhttp://hdl.handle.net/10261/137423
DOI10.3390/v7072786
ISSN1999-4915
Appears in Collections:(CNB) Artículos
Files in This Item:
File Description SizeFormat 
viruses-07-02786-v2.pdf740,45 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.