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Title

Antibacterial and antifungal activity of ZnO containing glasses

AuthorsEsteban-Tejeda, Leticia ; Prado, Catuxa ; Cabal, Belén ; Sanz Lázaro, Jesús; Torrecillas, Ramón ; Moya, J. S.
Issue Date2015
PublisherPublic Library of Science
CitationPLoS ONE 10(7): e0132709 (2015)
AbstractA new family of non-toxic biocides based on low melting point (1250°C) transparent glasses with high content of ZnO (15–40wt%) belonging to the miscibility region of the B2O3-SiO2-Na2O-ZnO system has been developed. These glasses have shown an excellent biocide activity (logarithmic reduction >3) against Gram- (E. coli), Gram+ (S. aureus) and yeast (C. krusei); they are chemically stable in different media (distilled water, sea-like water, LB and DMEN media) as well as biocompatible. The cytotoxicity was evaluated by the Neutral Red Uptake using NIH-3T3 (mouse embryonic fibroblast cells) and the cell viability was >80%. These new glasses can be considered in several and important applications in the field of inorganic non-toxic biocide agents such as medical implants, surgical equipment, protective apparels in hospitals, water purifications systems, food packaging, food storages or textiles.
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0132709
URIhttp://hdl.handle.net/10261/137373
DOI10.1371/journal.pone.0132709
Identifiersdoi: 10.1371/journal.pone.0132709
issn: 1932-6203
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