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Title

Structural traits and catalytic versatility of the lipases from the Candida rugosa-like family: A review

AuthorsBarriuso, Jorge ; Vaquero, María Eugenia ; Prieto, Alicia ; Martínez, María Jesús
KeywordsLipase
Sterol-esterase
Candida rugosa
Biocatalysts
Hydrophobic enzymes
Issue DateSep-2016
PublisherElsevier
CitationBiotechnology Advances 34 (5) 874–885 (2016 )
AbstractLipases and sterol esterases are enzymes with broad biotechnological applications, which catalyze the hydrolysis or synthesis of long-chain acylglycerols and sterol esters, respectively. In this paper, we review the current knowledge on the so-called Candida rugosa-like family of enzymes, whose members display in most cases affinity against the two substrates mentioned above. The family includes proteins with the α/β-hydrolase folding, sharing conserved motifs in their sequences, and common structural features. We will go through their production and purification, relate their described structures and catalytic activity, and discuss the influence of the hydrophobic character of these lipases on their aggregation state and activity. On the basis of the few crystal structures available, the role of each of the functional areas in catalysis will be analyzed. Considering the particular characteristics of this group, we propose their classification as “Versatile Lipases” (EC 3.1.1.x).
Description32 p.-4 fig.-1 tab.
Publisher version (URL)http://dx.doi.org/10.1016/j.biotechadv.2016.05.004
URIhttp://hdl.handle.net/10261/137065
DOI10.1016/j.biotechadv.2016.05.004
ISSN0734-9750
E-ISSN1873-1899
Appears in Collections:(CIB) Artículos
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