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Título

Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNA

AutorHernández-Aínsa, Silvia; Ricci, Maria; Hilton, Lloyd; Aviñó, Anna; Eritja Casadellà, Ramón; Keyser, Ulrich Felix
Palabras claveAzobenzene
DNA
Liposomes
Self-assembly
Stimuli-responsive materials
Fecha de publicación13-jul-2016
EditorAmerican Chemical Society
CitaciónNano Letters 16 (7): 4462-4466 (2016)
ResumenWe present a novel approach to reversibly control the assembly of liposomes through an anchored multistimuli responsive DNA oligonucleotide decorated with an azobenzene moiety (AZO-ON1). We show that liposomes assembly can be simultaneously controlled by three external stimuli: light, Mg2+, and temperature. (i) Light alters the interaction of AZO-ON1 with liposomes, which influences DNA coating and consequently liposomes assembly. (ii) Mg2+ induces the assembly, hence variation in its concentration enables for reversibility. (iii) Double-stranded AZO-ON1 is more efficient than single-stranded AZO-ON1 in triggering the assembly of liposomes and temperature has been used for controllable assembly through DNA thermal denaturation. Our multiresponsive AZO-ON1 represents a unique example in which multiple stimuli can be simultaneously applied to regulate the reversible assembly of liposomes. © 2016 American Chemical Society.
Versión del editorhttp://dx.doi.org/10.1021/acs.nanolett.6b01618
URIhttp://hdl.handle.net/10261/137026
DOI10.1021/acs.nanolett.6b01618
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