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Title

Peptide-PNA conjugates: Targeted transport of antisense therapeutics into tumors

AuthorsMier, Walter; Eritja Casadellà, Ramón; Mohammed, Ashour; Haberkorn, Uwe; Eisenhut, Michael
KeywordsAntisense agents
Drug delivery
Peptide nucleic acids
Peptides
Solid-phase synthesis
Issue Date29-Apr-2003
PublisherJohn Wiley & Sons
CitationAngewandte Chemie - International Edition 42 (17): 1968-1971(2003)
AbstractTumor-specific accumulation of antisense therapeutics: The conjugation of a receptor-binding peptide allows for the first time the selective transport of oligonucleotide analogues into tumor tissue. By using the tert-butyloxycarbonyl (Boc) protecting group stratergy, hybrids of peptide nucleic acids and peptides are accessible that accumulate in tumor tissue at a tenfold higher concentration than the free peptide nucleic acid.
Publisher version (URL)http://dx.doi.org/10.1002/anie.200219978
URIhttp://hdl.handle.net/10261/136724
DOI10.1002/anie.200219978
Appears in Collections:(IQAC) Artículos
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