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Efficient synthesis of single-chain polymer nanoparticles via amide formation

AutorSánchez-Sánchez, Ana; Pomposo, José A.
Fecha de publicación2015
EditorHindawi Publishing Corporation
CitaciónJournal of Nanomaterials: 723492 (2015)
ResumenSingle-chain technology (SCT) allows the transformation of individual polymer chains to folded/collapsed unimolecular soft nanoparticles. In this work we contribute to the enlargement of the SCT toolbox by demonstrating the efficient synthesis of single-chain polymer nanoparticles (SCNPs) via intrachain amide formation. In particular, we exploit cross-linking between active methylene groups and isocyanate moieties as powerful >click> chemistry driving force for SCNP construction. By employing poly(methyl methacrylate)- (PMMA-) based copolymers bearing β-ketoester units distributed randomly along the copolymer chains and bifunctional isocyanate cross-linkers, SCNPs were successfully synthesized at r.t. under appropriate reaction conditions. Characterization of the resulting SCNPs was carried out by means of a combination of techniques including size exclusion chromatography (SEC), infrared (IR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, dynamic light scattering (DLS), and elemental analysis (EA).
DescripciónThis is an open access article distributed under the Creative Commons Attribution License.
Versión del editorhttp://dx.doi.org/10.1155/2015/723492
Identificadoresdoi: 10.1155/2015/723492
e-issn: 1687-4129
issn: 1687-4110
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