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Efficient synthesis of single-chain polymer nanoparticles via amide formation

AuthorsSánchez-Sánchez, Ana; Pomposo, José A.
Issue Date2015
PublisherHindawi Publishing Corporation
CitationJournal of Nanomaterials: 723492 (2015)
AbstractSingle-chain technology (SCT) allows the transformation of individual polymer chains to folded/collapsed unimolecular soft nanoparticles. In this work we contribute to the enlargement of the SCT toolbox by demonstrating the efficient synthesis of single-chain polymer nanoparticles (SCNPs) via intrachain amide formation. In particular, we exploit cross-linking between active methylene groups and isocyanate moieties as powerful >click> chemistry driving force for SCNP construction. By employing poly(methyl methacrylate)- (PMMA-) based copolymers bearing β-ketoester units distributed randomly along the copolymer chains and bifunctional isocyanate cross-linkers, SCNPs were successfully synthesized at r.t. under appropriate reaction conditions. Characterization of the resulting SCNPs was carried out by means of a combination of techniques including size exclusion chromatography (SEC), infrared (IR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, dynamic light scattering (DLS), and elemental analysis (EA).
DescriptionThis is an open access article distributed under the Creative Commons Attribution License.
Publisher version (URL)http://dx.doi.org/10.1155/2015/723492
Identifiersdoi: 10.1155/2015/723492
e-issn: 1687-4129
issn: 1687-4110
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