English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/136341
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase

AuthorsSánchez-Gómez, Francisco J. ; Díez-Dacal, Beatriz ; García-Martín, Elena; Agúndez, José Augusto G.; Pajares, María A. ; Pérez-Sala, Dolores
KeywordsGlutathione transferase
Aldose reductase
Inflammation
Oxidative stress
Detoxification
Allergy
Drug adduct
Drug hypersensitivity
Issue Date4-Aug-2016
PublisherFrontiers Media
CitationFrontiers Pharmacology 7: 237 (2016)
AbstractPhase I and II enzymes are involved in the metabolism of endogenous reactive compounds as well as xenobiotics, including toxicants and drugs. Genotyping studies have established several drug metabolizing enzymes as markers for risk of drug hypersensitivity. However, other candidates are emerging that are involved in drug metabolism but also in the generation of danger or costimulatory signals. Enzymes such as aldo-keto reductases (AKR) and glutathione transferases (GST) metabolize prostaglandins and reactive aldehydes with proinflammatory activity, as well as drugs and/or their reactive metabolites. In addition, their metabolic activity can have important consequences for the cellular redox status, and impacts the inflammatory response as well as the balance of inflammatory mediators, which can modulate epigenetic factors and cooperate or interfere with drug-adduct formation. These enzymes are, in turn, targets for covalent modification and regulation by oxidative stress, inflammatory mediators, and drugs. Therefore, they constitute a platform for a complex set of interactions involving drug metabolism, protein haptenation, modulation of the inflammatory response, and/or generation of danger signals with implications in drug hypersensitivity reactions. Moreover, increasing evidence supports their involvement in allergic processes. Here, we will focus on GSTP1-1 and aldose reductase (AKR1B1) and provide a perspective for their involvement in drug hypersensitivity
Description9 p.-2 fig
Publisher version (URL)http://dx.doi.org/10.3389/fphar.2016.00237
URIhttp://hdl.handle.net/10261/136341
DOI10.3389/fphar.2016.00237
E-ISSN1663-9812
Appears in Collections:(CIB) Artículos
(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
fphar-Pérez-Sala 2016.pdfArtículo principal1,54 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.