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Título: | Carbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-End |
Autor: | Gomez-Pinto, Irene CSIC ORCID; Vengut-Climent, Empar; Lucas, Ricardo CSIC; Aviñó, Anna CSIC ORCID; Eritja Casadellà, Ramón CSIC ORCID ; Bustamante González, Carlos Alberto; Morales, Juan Carlos CSIC ORCID | Palabras clave: | carbohydrates DNA G-quadruplexes Hydrogen bonds molecular interactions Stacking |
Fecha de publicación: | 4-feb-2013 | Editor: | Wiley-VCH | Citación: | Chemistry - A European Journal 19 (6): 1920-1927 (2013) | Resumen: | Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, supramolecular chemistry to nanoscience. We have prepared carbohydrate-DNA conjugates containing the oligonucleotide sequences of G-quadruplexes (thrombin binding aptamer (TBA) and human telomere (TEL)), measured their thermal stability and studied their structure in solution by using NMR and molecular dynamics. The solution structure of a fucose-TBA conjugate shows stacking interactions between the carbohydrate and the DNA G-tetrad in addition to hydrogen bonding and hydrophobic contacts. We have also shown that attaching carbohydrates at the 5′-end of a quadruplex telomeric sequence can alter its folding topology. These results suggest the possibility of modulating the folding of the G-quadruplex by linking carbohydrates and have clear implications in molecular recognition and the design of new G-quadruplex ligands. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Versión del editor: | http://dx.doi.org/10.1002/chem.201203902 | URI: | http://hdl.handle.net/10261/136311 | DOI: | 10.1002/chem.201203902 |
Aparece en las colecciones: | (IQAC) Artículos |
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GomezPintoChemistry2013.pdf | 1,9 MB | Adobe PDF | Visualizar/Abrir |
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