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Título: | Glucose-Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA |
Autor: | Vengut-Climent, E.; Gomez-Pinto, Irene CSIC ORCID; Lucas, Ricardo CSIC; Peñalver, Pablo CSIC ORCID; Aviñó, Anna CSIC ORCID; Fonsecaguerra, Célia; Bickelhaupt, F. Matthias; Eritja Casadellà, Ramón CSIC ORCID ; Bustamante González, Carlos Alberto; Morales, Juan Carlos CSIC ORCID | Palabras clave: | DNA Hydrogen bonds NMR spectroscopy Noncovalent interactions Nucleobases |
Fecha de publicación: | 2016 | Editor: | John Wiley & Sons | Citación: | Angewandte Chemie - International Edition 2016 | Resumen: | Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside-RNA recognition, glucose-nucleobase pairs have been examined. Deoxyoligonucleotides with a 6-deoxyglucose insertion are able to hybridize with their complementary strand, thus exhibiting a preference for purine nucleobases. Although the resulting double helices are less stable than natural ones, they present only minor local distortions. 6-Deoxyglucose stays fully integrated in the double helix and its OH groups form two hydrogen bonds with the opposing guanine. This 6-deoxyglucose-guanine pair closely resembles a purine-pyrimidine geometry. Quantum chemical calculations indicate that glucose-purine pairs are as stable as a natural T-A pair. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Versión del editor: | http://dx.doi.org/10.1002/anie.201603510 | URI: | http://hdl.handle.net/10261/136297 | DOI: | 10.1002/anie.201603510 |
Aparece en las colecciones: | (IQAC) Artículos (IQF) Artículos (IIQ) Artículos |
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GlucoseVengutAngew2016.pdf | 2,94 MB | Adobe PDF | Visualizar/Abrir |
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