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dc.contributor.authorVengut-Climent, E.es_ES
dc.contributor.authorGomez-Pinto, Irenees_ES
dc.contributor.authorLucas, Ricardoes_ES
dc.contributor.authorPeñalver, Pabloes_ES
dc.contributor.authorAviñó, Annaes_ES
dc.contributor.authorFonsecaguerra, Céliaes_ES
dc.contributor.authorBickelhaupt, F. Matthiases_ES
dc.contributor.authorEritja Casadellà, Ramónes_ES
dc.contributor.authorBustamante González, Carlos Albertoes_ES
dc.contributor.authorMorales, Juan Carloses_ES
dc.date.accessioned2016-09-05T08:55:53Z-
dc.date.available2016-09-05T08:55:53Z-
dc.date.issued2016-
dc.identifier.citationAngewandte Chemie - International Edition 2016es_ES
dc.identifier.urihttp://hdl.handle.net/10261/136297-
dc.description.abstractNoncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside-RNA recognition, glucose-nucleobase pairs have been examined. Deoxyoligonucleotides with a 6-deoxyglucose insertion are able to hybridize with their complementary strand, thus exhibiting a preference for purine nucleobases. Although the resulting double helices are less stable than natural ones, they present only minor local distortions. 6-Deoxyglucose stays fully integrated in the double helix and its OH groups form two hydrogen bonds with the opposing guanine. This 6-deoxyglucose-guanine pair closely resembles a purine-pyrimidine geometry. Quantum chemical calculations indicate that glucose-purine pairs are as stable as a natural T-A pair. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.es_ES
dc.description.sponsorshipWe thank the Ministerio de Economía y Competitividad (CTQ2011- 15203-E, CTQ2012-35360, CTQ2014-52588-R, BFU2014-52864-R), the Netherlands Organization for Scientific Research (NWO-CW and NWO-EW), and the National Research School Combination—Catalysis (NRSC-C) for financial support. E.V.C. thanks Ministerio de Educación, Cultura y Deporte for a FPU fellowship and Cost Action CM1005 for a STSM grant.es_ES
dc.language.isoenges_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccessen_EN
dc.subjectDNAes_ES
dc.subjectHydrogen bondses_ES
dc.subjectNMR spectroscopyes_ES
dc.subjectNoncovalent interactionses_ES
dc.subjectNucleobaseses_ES
dc.titleGlucose-Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNAes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1002/anie.201603510-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1002/anie.201603510es_ES
dc.embargo.terms2017-09-01es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
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