Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/136086
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Long-term dietary folate deficiency accelerates progressive hearing loss on CBA/Ca mice |
Autor: | Martínez-Vega, Raquel CSIC; Murillo-Cuesta, Silvia CSIC ORCID; Partearroyo, Teresa; Varela-Moreiras, Gregorio; Varela-Nieto, Isabel CSIC ORCID ; Pajares, María A. CSIC ORCID | Fecha de publicación: | 2016 | Editor: | Frontiers Media | Citación: | Frontiers in Aging Neuroscience 8: 209 (2016) | Resumen: | Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after two-months, corroborating the epidemiological association previously described between vitamin deficiency and this sensory impairment. However, this strain is prone to early hearing loss, and hence we decided to analyze whether the effects exerted by folate deprivation follow the same pattern in a mouse strain such as CBA/Ca, which is resistant to hearing impairment. Here, we show results of a long-term study on hearing carried out on CBA/Ca mice subjected to dietary folate deprivation. Systemic changes included decreased serum folate levels, hyperhomocysteinemia and signs of anemia in the group fed the folate-deficient diet. Initial signs of hearing loss were detected in this strain after 8-months of vitamin deficiency, and correlated with histological damage in the cochleae. In conclusion, the data presented reinforce the importance of adequate folic acid levels for the auditory system and suggest that the impact of dietary deficiencies may depend on the genetic background. | Descripción: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). | Versión del editor: | http://dx.doi.org/10.3389/fnagi.2016.00209 | URI: | http://hdl.handle.net/10261/136086 | DOI: | 10.3389/fnagi.2016.00209 | E-ISSN: | 1663-4365 |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
CBACa Mice.pdf | 1,75 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
6
checked on 25-mar-2024
SCOPUSTM
Citations
12
checked on 20-mar-2024
WEB OF SCIENCETM
Citations
12
checked on 29-feb-2024
Page view(s)
260
checked on 27-mar-2024
Download(s)
351
checked on 27-mar-2024