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Cancer stem cells as a result of a reprogramming-like mechanism: implications in tumor development and treatment

AuthorsIglesias, Juan Manuel; García-Ramírez, Idoia ; Martín-Lorenzo, Alberto ; Ruiz-Roca, Lucía ; Sánchez García, Isidro
KeywordsEpithelial to mesenchymal transition (EMT)
Reprogramming-like disease
Pluripotency-related genes
Organ development
Mesenchymal to epithelial transition (MET)
Human cancer
Cancer stem cell (CSC) theory
Issue Date2014
PublisherJohn Wiley & Sons
CitationCancer Stem Cells: 61-77 (2014)
AbstractSeveral recent studies of the effect of oncogenes in stem cells in cancer development implicate that tumor reprogramming (where the maintenance of oncogene expression is not critical for the generation of differentiated tumor cells) might represent a potentially important mechanism of tumor development for many types of cancer and that, if this is the case, the oncogenes that initiate tumor formation might be dispensable for tumor progression and/or maintenance. The practical implications that this new point of view has for the therapy of cancer are obviously enormous. This chapter addresses the impact of these results toward a better understanding of carcinogenesis and proposes research avenues for tackling these issues in the future.
Identifiersdoi: 10.1002/9781118356203.ch5
isbn: 978-1-118-35616-6
Appears in Collections:(IBMCC) Libros y partes de libros
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