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Current concepts of how to eliminate cancer stem cells

AutorCampos-Sánchez, Elena; Romero-Camarero, Isabel ; Sánchez García, Isidro ; Cobaleda, César
Fecha de publicación2013
EditorCRC Press
CitaciónRole of Cancer Stem Cells in Cancer Biology and Therapy: 167-198 (2013)
ResumenAfter many years of struggle against the traditional theories, cancer stem cells (CSCs) are finally coming of age as the main responsible for the maintenance and relapse of human cancer. there are two main reasons for this fact. First, the enormous amount of quickly accumulating experimental evidences proving their existence and their contribution to cancer maintenance and survival in humans. Second, the patent e vidence of the very slow advance of our fight against cancer in the las 50 years. Indeed, althought early detection and screening programs have increased the chances of diagnosing cancer at very early stages, the prognosis for disseminated tumors is as dismal today as it was 5 decades ago. It is therefore clear that a new conceptual framework is required in our approach to treat cancer. The acknowledgement of the existence of CSCs provides this framework and opens new avenues for exploring therapeutic approaches. In this chapter we revise the most recent discoveries in the research aimed at the targeting and elimination of CSCs.
Identificadoresisbn: 978-1-4665-7735-0
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