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Cancer stem cells

AutorCobaleda, César ; Vicente-Dueñas, Carolina ; Romero-Camarero, Isabel ; Sánchez García, Isidro
Palabras claveCancer
Mouse models
Solid tumours
Stem cells
Fecha de publicación2012
EditorJohn Wiley & Sons
CitaciónEncyclopaedia of Life Sciences: (2012)
ResumenCancer stem cells (CSCs) are the pathological counterpart of normal somatic tissue stem cells. They possess the capacities to self-renew and to generate a more differentiated, rapidly dividing and expanding tumour progeny. Although they constitute just a small percentage of the tumour mass, they are responsible for its maintenance and, therefore, they should be the target of anticancer treatments. The existence of CSCs is still a matter of controversy for certain tumour types – some of which are actually frequent and clinically relevant – but it is confirmed in many others. Moreover, CSCs are predictably genetically diverse, and their frequency and phenotype can vary in the course of the disease. However, CSCs have nowadays been identified in almost all the frequent types of tumours, and recent findings have shown that CSC gene expression signatures can be predictive of adverse clinical outcome, therefore maintaining the study of CSCs at the forefront of cancer research.
Identificadoresdoi: 10.1002/9780470015902.a0020860.pub2
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