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Title

CD53

AuthorsLazo, Pedro A. ; Barcia, R.
KeywordsOx-44
OX44
MOX44
Tspan25l
Cell surface glycoprotein CD53
CD53 antigen
Tetraspanin-25
Tspan-25
Leukocyte surface antigen CD53
Issue Date2012
PublisherSpringer
CitationEncyclopedia of Signalling Molecules: 343-347 (2012)
AbstractCD53 is one of the least characterized members of the tetraspanin family. CD53 is integrated in the tetraspanin web, and sends intracellular signals, directly or indirectly via PKC, AKT, and γ-glutamyl transpeptidase (GGT). Its expression can affect cell survival, resistance to apoptosis, and radiation sensitivity. In B-cell development CD53 is a marker of mature B cells. In human B-cell malignancies, the pattern of tetraspanin expression identifies the developmental stage of the corresponding tumors. The pattern of tetraspanins can be used to differentiate B-cell malignancies in an individual patient with several lymphoid tumors.
URIhttp://hdl.handle.net/10261/136021
DOI10.1007/978-1-4419-0461-4_566
Identifiersdoi: 10.1007/978-1-4419-0461-4_566
isbn: 978-1-4419-0460-7
Appears in Collections:(IBMCC) Libros y partes de libros
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