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AuthorsBlanco, Sandra ; Fernández, Isabel F. ; Vázquez-Cedeira, Marta ; Monsalve, Diana M. ; Merced, Triana ; Lazo, Pedro A.
KeywordsVaccinia virus B1R-related kinase 2
Vaccinia-related kinase 2
Issue Date2012
CitationEncyclopedia of Signalling Molecules: 1996-2000 (2012)
AbstractVRK2 is a Ser-Thr kinase and has two isoforms, cytosolic and nuclear. The full-length VRK2 cytosolic isoform (A) inhibits MAPK signaling by a direct interaction with the corresponding JIP1 or KSR1 scaffold proteins. As a consequence, high levels of VRK2A inhibit in a dose-dependent manner signals mediated by the TAK1-MKK7-JNK in response to hypoxia or interleukin, and the signal of the ERBB2-RAS-RAF-MEK-ERK pathway. Downregulation of VRK2A relieves this inhibition and allows signal transmission in response to stimuli initiated in receptor-tyrosine kinases (RTK), such as ERBB2. Thus, in breast cancer VRK2A and ERBB2 present an inverse correlation.
Identifiersdoi: 10.1007/978-1-4419-0461-4_562
isbn: 978-1-4419-0460-7
Appears in Collections:(IBMCC) Libros y partes de libros
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