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Genetic/molecular alterations of meningiomas and the signaling pathways targeted

AuthorsDomingues, Patricia H.; González-Tablas, María; Otero, Álvaro; Sousa, Pablo; Gonçalves, Jesús; Lopes, Maria Celeste; Orfao, Alberto ; Tabernero, María D.
Issue Date2015
PublisherImpact Journals
CitationOncotarget 6(13): 10671-10688 (2015)
AbstractMeningiomas are usually considered to be benign central nervous system tumors; however, they show heterogenous clinical, histolopathological and cytogenetic features associated with a variable outcome. In recent years important advances have been achieved in the identification of the genetic/molecular alterations of meningiomas and the signaling pathways involved. Thus, monosomy 22, which is often associated with mutations of the NF2 gene, has emerged as the most frequent alteration of meningiomas; in addition, several other genes (e.g. AKT1, KLF4, TRAF7, SMO) and chromosomes have been found to be recurrently altered often in association with more complex karyotypes and involvement of multiple signaling pathways. Here we review the current knowledge about the most relevant genes involved and the signaling pathways targeted by such alterations. In addition, we summarize those proposals that have been made so far for classification and prognostic stratification of meningiomas based on their genetic/genomic features.
DescriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.
Publisher version (URL)http://dx.doi.org/10.18632/oncotarget.3870
Identifiersdoi: 10.18632/oncotarget.3870
e-issn: 1949-2553
Appears in Collections:(IBMCC) Artículos
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