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Título

Analysis of the pathogenic potential of nosocomial Pseudomonas putida strains

AutorFernández Rodríguez, Matilde; Porcel Vílchez, Mario; Torre Zúñiga, Jesús de la; Molina Henares, María Antonia; Daddaoua, Abdelali; Llamas Llorente, María de los Ángeles; Roca Hernández, Amalia; Carriel Araya, Victor; Garzón Bello, Ingrid Johanna; Ramos Marín, Juan Luis; Alaminos Mingorance, Miguel; Duque Martín de la Oliva, Estrella
Palabras clavePseudomonas putida
Infecciones hospitalarias
Bacterias patógenas
Virulencia microbiana
Fecha de publicación25-ago-2015
EditorFrontiers Media
CitaciónFrontiers in Microbiology
ResumenPseudomonas putida strains are ubiquitous in soil and water but have also been reported as opportunistic human pathogens capable of causing nosocomial infections. In this study we describe the multilocus sequence typing of four P. putida strains (HB13667, HB8234, HB4184, and HB3267) isolated from in-patients at the Besançon Hospital (France). The four isolates (in particular HB3267) were resistant to a number of antibiotics. The pathogenicity and virulence potential of the strains was tested ex vivo and in vivo using different biological models: human tissue culture, mammalian tissues, and insect larvae. Our results showed a significant variability in the ability of the four strains to damage the host; HB13667 did not exhibit any pathogenic traits, HB4184 caused damage only ex vivo in human tissue cultures, and HB8234 had a deleterious effect in tissue culture and in vivo on rat skin, but not in insect larvae. Interestingly, strain HB3267 caused damage in all the model systems studied. The putative evolution of these strains in medical environments is discussed.
DescripciónThe Supplementary Material for this article can be found online at: http://journal.frontiersin.org/article/10.3389/fmicb.2015.00871
Versión del editordoi: 10.3389/fmicb.2015.00871
URIhttp://hdl.handle.net/10261/135559
E-ISSN1664-302X
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fmicb-06-00871.pdfFront. Microbiol., 25 August 2015 | http://dx.doi.org/10.3389/fmicb.2015.008713,52 MBAdobe PDFVista previa
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