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dc.contributor.authorGascon, Mireiaes_ES
dc.contributor.authorVrijheid, Martinees_ES
dc.contributor.authorGarí, Mercèes_ES
dc.contributor.authorFort, Martaes_ES
dc.contributor.authorGrimalt, Joan O.es_ES
dc.contributor.authorMartínez, David Paréses_ES
dc.contributor.authorTorrent, Matieses_ES
dc.contributor.authorGuxens, M.es_ES
dc.contributor.authorSunyer, J.es_ES
dc.identifier.citationEnvironmental International 74: 144-151(2015)es_ES
dc.description.abstractIntroduction: The aims of the present study are to assess the temporal trends of organochlorine compounds (OCs) concentrations and total serum burdens from birth until adolescence and the influence of breastfeeding in these temporal trends. Methods: In 1997 two birth cohort studies were set up in Ribera d'Ebre (N=102) and the island of Menorca (N=482), Spain. Concentrations (ng/mL) of OCs [pentachlorobenzene (PeCB), four isomers of hexachlorocyclohexane (HCH), hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (4,4'-DDT), dichlorodiphenyldichloroethylene (4,4'-DDE) and seven polychlorobiphenyl congeners (σ7PCBs)] were measured in cord blood and at the age of 4 and 14years. The total serum burdens (ng) of these compounds were estimated based on the total blood volume (mL) of children at the different ages. We compared median concentrations and total serum burdens of these OCs at the different time-points of follow-up between children of Ribera d'Ebre and Menorca and between breastfed and non-breastfed children. Results: From birth until adolescence concentrations of all OCs drastically reduced. These reductions were mainly derived from the dilution of OCs, associated to an increase in total blood volume of children at the age of 4 and 14years. Despite the reduction in OCs concentrations, the total serum burdens of 4,4'-DDE and σ7PCBs, were higher in adolescents than at birth. Increases in OCs total serum burden occurred both in breastfed and non-breastfed children, but were significantly higher in the first. Conclusions: Even after decades of banning OCs production and use, current young generations in westernized countries are still bioaccumulating these compounds. Given the potential health effects of OCs, especial attention should be paid in the control of secondary emissions in the environment and in the control of food production and contamination. In countries with endemic malaria it is important to work towards effective alternatives to the use of DDT. © 2014 Elsevier Ltd.es_ES
dc.description.sponsorshipThis study was supported by grants from the Spanish Ministry of Health (FIS-97/1102, FIS 97/0588, 00/0021-2, PI061756, PS0901958 and FIS PS09/00362), the Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0041), Fundació La Caixa (97/009-00 and 00/077-00), and the Generalitat de Catalunya-CIRIT 1999SGR 00241. Finally, the authors would like to be grateful to the families in Flix and Menorca participating in the study, to the high school management team of Flix for their interest and collaboration, and to Rosa Maria Sabaté, the nurse of the health center of Flix, for her support and commitment.es_ES
dc.subjectOrganochlorine compoundses_ES
dc.titleTemporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeedinges_ES
dc.description.peerreviewedPeer reviewedes_ES
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