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dc.contributor.authorRobinson, Oliveres_ES
dc.contributor.authorBasagaña, X.es_ES
dc.contributor.authorAgier, Lydianees_ES
dc.contributor.authorDe Castro, Montserrates_ES
dc.contributor.authorHernandez-Ferrer, Carleses_ES
dc.contributor.authorGonzález, Juan Ramónes_ES
dc.contributor.authorGrimalt, Joan O.es_ES
dc.contributor.authorNieuwenhuijsen, M. J.es_ES
dc.contributor.authorSunyer, J.es_ES
dc.contributor.authorSlama, Rémyes_ES
dc.contributor.authorVrijheid, Martinees_ES
dc.identifier.citationEnvironmental Science and Technology - Columbuses_ES
dc.description.abstractThe "exposome" is defined as "the totality of human environmental exposures from conception onward, complementing the genome" and its holistic approach may advance understanding of disease etiology. We aimed to describe the correlation structure of the exposome during pregnancy to better understand the relationships between and within families of exposure and to develop analytical tools appropriate to exposome data. Estimates on 81 environmental exposures of current health concern were obtained for 728 women enrolled in The INMA (INfancia y Medio Ambiente) birth cohort, in Sabadell, Spain, using biomonitoring, geospatial modeling, remote sensors, and questionnaires. Pair-wise Pearson's and polychoric correlations were calculated and principal components were derived. The median absolute correlation across all exposures was 0.06 (5th-95th centiles, 0.01-0.54). There were strong levels of correlation within families of exposure (median = 0.45, 5th-95th centiles, 0.07-0.85). Nine exposures (11%) had a correlation higher than 0.5 with at least one exposure outside their exposure family. Effectively all the variance in the data set (99.5%) was explained by 40 principal components. Future exposome studies should interpret exposure effects in light of their correlations to other exposures. The weak to moderate correlation observed between exposure families will permit adjustment for confounding in future exposome studies. (Figure Presented). © 2015 American Chemical Society.es_ES
dc.description.sponsorshipWe would like to thank all INMA researchers on whose previous work this study is based. We thank all the INMA study participants and the members of the HELIX-EXPOsOMICs statistical working group who provided helpful discussions This research received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under Grant Agreement 308333−the HELIX project. The INMA Sabadell cohort was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041), Spanish Ministry of Health (FIS-PI041436, FIS- PI081151), Generalitat de Catalunya (CIRIT 1999SGR 00241), Fondo de Investigacion Sanitaria (ISCIII: FIS-PI12/01890), Fundació La Marató De TV3 (090430), and Recercaixa (2010ACUP 00349). We acknowledge the following studies, funded by the European Community’s Sixth and Seventh Framework Programmes, for generating exposure estimates used in this analysis: The ESCAPE study (Grant 211250) provided estimates on exposure to air pollutants; the HIWATE study (Contract No. Food-CT-2006-036224) provided estimates on exposure to water disinfection byproducts; and the PHENOTYPE study (Grant 282996) provided estimates on green spaces.es_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectEnvironmental exposurees_ES
dc.subjectGeospatial modeles_ES
dc.subject4,4' isopropylidenediphenoles_ES
dc.subjectpregnancy exposomees_ES
dc.titleThe Pregnancy Exposome: Multiple Environmental Exposures in the INMA-Sabadell Birth Cohortes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderEuropean Commissiones_ES
oprm.item.hasRevisionno ko 0 false*
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