English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/135136
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

The Pregnancy Exposome: Multiple Environmental Exposures in the INMA-Sabadell Birth Cohort

AuthorsRobinson, Oliver; Basagaña, X.; Agier, Lydiane; De Castro, Montserrat; Hernandez-Ferrer, Carles; González, Juan Ramón; Grimalt, Joan O. ; Nieuwenhuijsen, M. J.; Sunyer, J.; Slama, Rémy; Vrijheid, Martine
KeywordsEnvironmental exposure
Geospatial model
4,4' isopropylidenediphenol
pregnancy exposome
Issue Date1-Sep-2015
PublisherAmerican Chemical Society
CitationEnvironmental Science and Technology - Columbus
AbstractThe "exposome" is defined as "the totality of human environmental exposures from conception onward, complementing the genome" and its holistic approach may advance understanding of disease etiology. We aimed to describe the correlation structure of the exposome during pregnancy to better understand the relationships between and within families of exposure and to develop analytical tools appropriate to exposome data. Estimates on 81 environmental exposures of current health concern were obtained for 728 women enrolled in The INMA (INfancia y Medio Ambiente) birth cohort, in Sabadell, Spain, using biomonitoring, geospatial modeling, remote sensors, and questionnaires. Pair-wise Pearson's and polychoric correlations were calculated and principal components were derived. The median absolute correlation across all exposures was 0.06 (5th-95th centiles, 0.01-0.54). There were strong levels of correlation within families of exposure (median = 0.45, 5th-95th centiles, 0.07-0.85). Nine exposures (11%) had a correlation higher than 0.5 with at least one exposure outside their exposure family. Effectively all the variance in the data set (99.5%) was explained by 40 principal components. Future exposome studies should interpret exposure effects in light of their correlations to other exposures. The weak to moderate correlation observed between exposure families will permit adjustment for confounding in future exposome studies. (Figure Presented). © 2015 American Chemical Society.
Publisher version (URL)http://dx.doi.org/10.1021/acs.est.5b01782
URIhttp://hdl.handle.net/10261/135136
DOI10.1021/acs.est.5b01782
Appears in Collections:(IDAEA) Artículos
Files in This Item:
File Description SizeFormat 
robinsonetal2015 es&t.pdf1,59 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.