English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/135058
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorJarque, Sergioes_ES
dc.contributor.authorQuirós, Laiaes_ES
dc.contributor.authorGrimalt, Joan O.es_ES
dc.contributor.authorGallego, Evaes_ES
dc.contributor.authorCatalán, Jordies_ES
dc.contributor.authorLackner, Reinhardes_ES
dc.contributor.authorPiña, Benjamínes_ES
dc.identifier.citationScientific Reports 5(11292)es_ES
dc.description.abstractHuman activity has spread trace amounts of chemically stable endocrine-disrupting pollutants throughout the biosphere. These compounds have generated a background level of estrogenic activity that needs to be assessed. Fish are adequate sentinels for feminization effects as male specimens are more sensitive than humans to exogenous estrogenic compounds. High mountain lakes, the most distant environments of continental areas, only receive semi-volatile compounds from atmospheric deposition. We analyzed the expression levels of estrogen-regulated genes in male fish from these mountain lakes in Europe. Incipient feminization involving expression of estrogen receptor and zona radiata genes revealed a widespread diffuse estrogenic impact. This effect was correlated with the concentrations of some organochlorine compounds in fish and was consistent with the persistent occurrence of these tropospheric pollutants in the most remote planet regions. These results should be of general concern given the increasing endocrine disruption effects in human populations. © 2015, Nature Publishing Group. All rights reserved.es_ES
dc.description.sponsorshipWe acknowledge financial support from the EU projects, EUROLIMPACS, CROME-LIFE, HEALS, and the Spanish project, Consolider-Ingenio GRACCIE.es_ES
dc.publisherNature Publishing Groupes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectFeminization effectses_ES
dc.subjectEndocrine disruptiones_ES
dc.titleBackground fish feminization effects in European remote siteses_ES
dc.description.peerreviewedPeer reviewedes_ES
oprm.item.hasRevisionno ko 0 false*
Appears in Collections:(IDAEA) Artículos
Files in This Item:
File Description SizeFormat 
srep11292.pdfArtículo principal661,62 kBAdobe PDFThumbnail
srep11292-s1.pdfInformación suplementaria71,84 kBAdobe PDFThumbnail
Show simple item record

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.