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| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Tyrkalska, Sylwia | es_ES |
| dc.contributor.author | Mulero, Victoriano | es_ES |
| dc.date.accessioned | 2016-07-22T10:09:15Z | - |
| dc.date.available | 2016-07-22T10:09:15Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier.citation | Nature Communications 7: 12077 (2016) | es_ES |
| dc.identifier.issn | 2041-1723 | - |
| dc.identifier.uri | http://hdl.handle.net/10261/134980 | - |
| dc.description | 17 páginas, 10 figuras.-- Sylwia Tyrkalska ... et al.-- This work is licensed under a Creative Commons Attribution 4.0 International License | es_ES |
| dc.description.abstract | Inflammasomes are cytosolic molecular platforms that alert the immune system about the presence of infection. Here we report that zebrafish guanylate-binding protein 4 (Gbp4), an IFNγ-inducible GTPase protein harbouring a C-terminal CARD domain, is required for the inflammasome-dependent clearance of Salmonella Typhimurium (ST) by neutrophils in vivo. Despite the presence of the CARD domain, Gbp4 requires the universal inflammasome adaptor Asc for mediating its antibacterial function. In addition, the GTPase activity of Gbp4 is indispensable for inflammasome activation and ST clearance. Mechanistically, neutrophils are recruited to the infection site through the inflammasome-independent production of the chemokine (CXC motif) ligand 8 and leukotriene B4, and then mediate bacterial clearance through the Gbp4 inflammasome-dependent biosynthesis of prostaglandin D2. Our results point to GBPs as key inflammasome adaptors required for prostaglandin biosynthesis and bacterial clearance by neutrophils and suggest that transient activation of the inflammasome may be used to treat bacterial infections | es_ES |
| dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy and Competiveness (grants BIO2011-23400 and BIO2014-52655-R to V.M., AGL2012-39674 to M.P.S., and BIO2013-45336-R to A.S.-F. and PhD fellowships to S.C., D.A. and V.G.-A., all co-funded with Fondos Europeos de Desarrollo Regional/European Regional Development Funds), the European 7th Framework Initial Training Network FishForPharma (PhD fellowship to S.D.T., PITG-GA-2011-289209), the Sara Borrell postdoc grant from the Instituto Salud Carlos III to F.M.-S. (CD12/00523) and the European Research Council (ERC-2013-CoG 614578 to P.P.) | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Nature Publishing Group | es_ES |
| dc.relation.isversionof | Publisher's version | es_ES |
| dc.rights | openAccess | es_ES |
| dc.title | Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins | es_ES |
| dc.type | artículo | es_ES |
| dc.identifier.doi | 10.1038/ncomms12077 | - |
| dc.description.peerreviewed | Peer reviewed | es_ES |
| dc.relation.publisherversion | http://dx.doi.org/10.1038/ncomms12077 | es_ES |
| dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | es_ES |
| dc.relation.csic | Sí | es_ES |
| oprm.item.hasRevision | no ko 0 false | * |
| dc.identifier.pmid | 27363812 | - |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
| item.openairetype | artículo | - |
| item.grantfulltext | open | - |
| item.cerifentitytype | Publications | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.fulltext | With Fulltext | - |
| item.languageiso639-1 | en | - |
| Aparece en las colecciones: | (IIM) Artículos | |
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|---|---|---|---|---|
| Neutrophils_mediate_salmonella_2016.pdf | 3,28 MB | Adobe PDF |  Visualizar/Abrir |
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