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Title

BAX and BCL-2 polymorphisms, as predictors of proliferative vitreoretinopathy development in patients suffering retinal detachment: the Retina 4 project

AuthorsPastor-Idoate, Salvador; Rodríguez-Hernández, Irene; González-Sarmiento, Rogelio ; Pastor, Jose Carlos
KeywordsNecroptosis
Proliferative vitreoretinopathy
Retinal detachment
Bax
Bcl-2
Apoptosis
Issue Date2015
PublisherJohn Wiley & Sons
CitationActa Ophthalmologica 93(7): e541-e549 (2015)
Abstract[Purpose]: To compare the distribution of BCL-2 -938C>A (rs2279115) and BAX -248G>A (rs4645878) genotypes among European subjects undergoing rhegmatogenous retinal detachment (RRD) surgery in relation to the further development of proliferative vitreoretinopathy (PVR). [Methods]: A case-control gene association study, as a part of Retina 4 project, was designed. rs2279115 and rs4645878 polymorphisms were analysed in 555 samples from patients with RRD (134 with PVR secondary to surgery). Proportions of genotypes and AA homozygous groups of BCL-2 and BAX polymorphisms between subsamples were analysed in two phases. Genotypic and allelic frequencies were compared in global sample and in subsamples. [Results]: BAX: Differences were observed in the genotype frequencies and in AA carriers between controls and cases in the global series. The odds ratio (OR) of A carriers in the global sample was 1.7 (95% CI: 1.23-2.51). Proportions of genotypes in Spain + Portugal were significant different. The OR of A carriers from Spain and Portugal was 1.8 (95% CI: 1.11-2.95). BCL-2: No significant differences were observed in genotype frequencies. However, proportions of genotypes in Spain + Portugal were significant. A protective effect (OR: 0.6 95% CI: 0.43-0.96) was found in A carriers from Spain and Portugal. [Conclusions]: Results suggest that A allele of rs4645878 could be a biomarker of high risk of developing PVR in patients undergoing RD surgery. The possible role of BCL-2 (inhibitor of necroptosis pathway) as a possible new target in PVR prophylaxis should be investigated.
DescriptionGenetics on PVR Study Group: et al.
Meeting Presentation: EVER Annual Meeting, Nice, October 2014 as a poster and rapid paper.
URIhttp://hdl.handle.net/10261/134839
DOI10.1111/aos.12718
Identifiersdoi: 10.1111/aos.12718
e-issn: 1755-3768
Appears in Collections:(IBMCC) Artículos
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