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Identification and characterization of a novel tick-borne flavivirus subtype in goats (Capra hircus) in Spain

AutorMansfield, Karen L.; Balseiro, Ana; Ayllón, Nieves ; Höfle, Ursula ; Alberdi, Pilar ; Fernández de Mera, Isabel G.; García Marín, Juan Francisco ; Gortázar, Christian ; Fuente, José de la
Palabras claveLouping-Ill Virus
Encephalitis-Virus
Nonstructural Proteins
Rna Replication
Great-Britain
Stranded Rna
Region
Sheep
Ns2a
Inhibition
Fecha de publicación2015
EditorMicrobiology Society
CitaciónJournal of General Virology 96(7): 1676-1681 (2015)
ResumenIn 2011, a neurological disease was reported in a herd of goats (Capra hircus) in Asturias, Spain. Initial sequencing identified the causative agent as louping ill virus (LIV). Subsequently, with the application of whole genome sequencing and phylogenetic analysis, empirical data demonstrates that the LIV-like virus detected is significantly divergent from LIV and Spanish sheep encephalitis virus (SSEV). This virus encoded an amino acid sequence motif at the site of a previously identified marker for differentiating tick-borne flaviviruses that was shared with a virus previously isolated in Ireland in 1968. The significance of these observations reflects the diversity of tick-borne flaviviruses in Europe. These data also contribute to our knowledge of the evolution of tick-borne flaviviruses and could reflect the movement of viruses throughout Europe. Based on these observations, the proposed name for this virus is Spanish goat encephalitis virus (SGEV), to distinguish it from SSEV.
Descripción6 páginas.-- Mansfield, K. L. (et al.).
Versión del editorhttp://dx.doi.org/10.1099/vir.0.000096
URIhttp://hdl.handle.net/10261/134818
DOI10.1099/vir.0.000096
ISSN0022-1317
E-ISSN1465-2099
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