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Title

Screening pulmonary arteriovenous malformations in a large cohort of Spanish patients with hemorrhagic hereditary telangiectasia

AuthorsParra, José A.; Cuesta, José María; Zarrabeitia, Roberto; Fariñas-Álvarez, Concepción; Bueno, Jesús; Marqués, Sarah; Parra-Fariñas, Carmen; Botella, Luisa María CSIC ORCID ; Bernabéu, Carmelo CSIC ORCID ; Zarauza, Jesús
KeywordsHereditary hemorrhagic telangiectasia
Pulmonary arteriovenous malformations
Transthoracic contrast echocardiography
Computed tomography
Ultrasound contrast agents
Issue Date1-Sep-2016
PublisherElsevier
CitationInt J Cardiol. 218: 240-5 ( 2016)
AbstractBackground and objectives Because of the serious nature of potential complications, screening for pulmonary arteriovenous malformations is required in patients with hereditary hemorrhagic telangiectasia. The aim of this study was to evaluate the utility of contrast echocardiography and compare the performance of two contrast agents: agitated saline and Gelofusine.
Material and methods Two hundred and five patients screened for PAVMs using TTCE and computed tomography (CT) performed with an interval of less than 180 days. Contrast echocardiography studies were graded on a 4-point semiquantitative scale based on the amount of microbubbles seen in left heart chambers.
Results Positive TTCE findings were seen in 137 (66.8%) patients, whereas CT confirmed PAVMs in 59 (43.1%). Two of 67 grade 1 patients; 18 of 42 grade 2; 17 of 22 grade 3 and all grade 4 had PAVMs on CT. Embolotherapy was feasible in 38.9% patients in grade 2 and 82.3% and 95.2% in grades 3–4. No patients in grade 1 were embolized. The mean cardiac cycle in which bubbles were first seen in the left heart in patients without and with PAVMs on CT was 6.1 and 3.9 (p < 0.0001). Compared to saline, Gelofusine produced an overall increase in grade.
Conclusions No grade 1 patients had treatable PAVMs. There is a need for improvement in the selection of patients for CT in grade 2, where less than half have PAVMs on CT. The cardiac cycle may help to differentiate between patients with and without PAVMs. Gelofusine was not better than saline for PAVM screening.
Description39 p.-1 fig.-7 tab.
Publisher version (URL)http://dx.doi.org/10.1016/j.ijcard.2016.05.065
URIhttp://hdl.handle.net/10261/134794
DOI10.1016/j.ijcard.2016.05.065
ISSN0167-5273
E-ISSN1874-1754
Appears in Collections:(CIB) Artículos

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