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Cytotoxic sesquiterpenes from Aplysia dactylomela

AuthorsDias, Teresa; Brito, Inmaculada ; Moujir, Laila; Paiz, Nuria; Darias, José ; Cueto, Mercedes
Issue Date14-Oct-2005
PublisherAmerican Chemical Society
American Society of Pharmacognosy
CitationJournal of Natural Products 68(11): 1677-1679 (2005)
AbstractThree new chamigrenes, compound 1, acetyldeschloroelatol 2 (2-bromo-1,1,9-trimethyl-5-methylenespiro[5.5]undec-8-en-3-yl acetate), and acetylelatol 4 (2-bromo-8-chloro-1,1,9-trimethyl-5-methylenespiro[5.5]undec-8-en-3-yl acetate), and the known metabolites deschloroelatol 3, elatol 5, 8-acetylcaespitol 6, and caespitol 7 have been isolated from the sea hare Aplysia dactylomela. The structures of 1, 2, and 4 were determined on the basis of spectroscopic evidences. The in vitro cytotoxicity of six of these compounds against two cancer cell lines (HeLa and Hep-2) and nontumoral Vero cells was evaluated. The results support the hypothesis that the acetate derivatives decrease the toxicity of the corresponding alcohols in a strategy to store toxic metabolites acquired through the diet.
Description3 pages, 1 figure, 2 tables.-- PMID: 16309323 [PubMed].-- Printed version published Nov 28, 2005.
Publisher version (URL)http://dx.doi.org/10.1021/np050240y
Appears in Collections:(IPNA) Artículos
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