English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/13468
Título

Cytotoxic sesquiterpenes from Aplysia dactylomela

AutorDias, Teresa; Brito, Inmaculada ; Moujir, Laila; Paiz, Nuria; Darias, José ; Cueto, Mercedes
Fecha de publicación14-oct-2005
EditorAmerican Chemical Society
American Society of Pharmacognosy
CitaciónJournal of Natural Products 68(11): 1677-1679 (2005)
ResumenThree new chamigrenes, compound 1, acetyldeschloroelatol 2 (2-bromo-1,1,9-trimethyl-5-methylenespiro[5.5]undec-8-en-3-yl acetate), and acetylelatol 4 (2-bromo-8-chloro-1,1,9-trimethyl-5-methylenespiro[5.5]undec-8-en-3-yl acetate), and the known metabolites deschloroelatol 3, elatol 5, 8-acetylcaespitol 6, and caespitol 7 have been isolated from the sea hare Aplysia dactylomela. The structures of 1, 2, and 4 were determined on the basis of spectroscopic evidences. The in vitro cytotoxicity of six of these compounds against two cancer cell lines (HeLa and Hep-2) and nontumoral Vero cells was evaluated. The results support the hypothesis that the acetate derivatives decrease the toxicity of the corresponding alcohols in a strategy to store toxic metabolites acquired through the diet.
Descripción3 pages, 1 figure, 2 tables.-- PMID: 16309323 [PubMed].-- Printed version published Nov 28, 2005.
Versión del editorhttp://dx.doi.org/10.1021/np050240y
URIhttp://hdl.handle.net/10261/13468
DOI10.1021/np050240y
ISSN1520-6025 (Online)
0163-3864 (Print)
Aparece en las colecciones: (IPNA) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.