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Proposal for a new risk stratification classification for meningioma based on patient age, WHO tumor grade, size, localization, and karyotype

AutorDomingues, Patricia H.; Sousa, Pablo; Otero, Álvaro; Gonçalves, Jesús; Lopes, Maria Celeste; Orfao, Alberto ; Tabernero, María D.
Palabras claveRisk stratification
Meningioma
iFISH
Recurrence
SNP arrays
Fecha de publicación2014
EditorOxford University Press
CitaciónNeuro-Oncology 16(5): 735-747 (2014)
Resumen[Background]: Tumor recurrence remains the major clinical complication of meningiomas, the majority of recurrences occurring among WHO grade I/benign tumors. In the present study, we propose a new scoring system for the prognostic stratification of meningioma patients based on analysis of a large series of meningiomas followed for a median of >5 years. [Methods]: Tumor cytogenetics were systematically investigated by interphase fluorescence in situ hybridization in 302 meningioma samples, and the proposed classification was further validated in an independent series of cases (n = 132) analyzed by high-density (500K) single-nucleotide polymorphism (SNP) arrays. [Results]: Overall, we found an adverse impact on patient relapse-free survival (RFS) for males, presence of brain edema, younger patients (<55 years), tumor size >50 mm, tumor localization at intraventricular and anterior cranial base areas, WHO grade II/III meningiomas, and complex karyotypes; the latter 5 variables showed an independent predictive value in multivariate analysis. Based on these parameters, a prognostic score was established for each individual case, and patients were stratified into 4 risk categories with significantly different (P <. 001) outcomes. These included a good prognosis group, consisting of approximately 20% of cases, that showed a RFS of 100% ± 0% at 10 years and a very poor-prognosis group with a RFS rate of 0% ± 0% at 10 years. The prognostic impact of the scoring system proposed here was also retained when WHO grade I cases were considered separately (P <. 001). [Conclusions]: Based on this risk-stratification classification, different strategies may be adopted for follow-up, and eventually also for treatment, of meningioma patients at different risks for relapse.
URIhttp://hdl.handle.net/10261/134651
DOI10.1093/neuonc/not325
Identificadoresdoi: 10.1093/neuonc/not325
e-issn: 1523-5866
issn: 1522-8517
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