English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/134631
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids

AuthorsSánchez-Blanco, Adolfo ; Rodríguez-Matellán, Alberto G.; Reis-Sobreiro, M.; Sáenz-Narciso, Beatriz; Cabello, Juan ; Mohler, William A.; Mollinedo, Faustino
KeywordsAlkylphospholipid analogs
Edelfosine
Tumor cell
Miltefosine
Mechanism of action
Embryo insulin/IGF-1 signaling
Antitumor lipids
Caenorhabditis elegans
Cholesterol
Issue Date2014
PublisherTaylor & Francis
CitationCell Cycle 13(21): 3375-3389 (2014)
AbstractDrugs capable of specifically recognizing and killing cancer cells while sparing healthy cells are of great interest in anti-cancer therapy. An example of such a drug is edelfosine, the prototype molecule of a family of synthetic lipids collectively known as antitumor lipids (ATLs). A better understanding of the selectivity and the mechanism of action of these compounds would lead to better anticancer treatments. Using Caenorhabditis elegans, we modeled key features of the ATL selectivity against cancer cells. Edelfosine induced a selective and direct killing action on C. elegans embryos, which was dependent on cholesterol, without affecting adult worms and larvae. Distinct ATLs ranked differently in their embryonic lethal effect with edelfosine > perifosine > erucylphosphocholine >> miltefosine. Following a biased screening of 57 C. elegans mutants we found that inactivation of components of the insulin/IGF-1 signaling pathway led to resistance against the ATL edelfosine in both C. elegans and human tumor cells. This paper shows that C. elegans can be used as a rapid platform to facilitate ATL research and to further understand the mechanism of action of edelfosine and other synthetic ATLs.
URIhttp://hdl.handle.net/10261/134631
DOI10.4161/15384101.2014.952183
Identifiersdoi: 10.4161/15384101.2014.952183
e-issn: 1551-4005
issn: 1538-4101
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.