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Título

Elenoside increases intestinal motility

AutorNavarro, Eduardo; Alonso, Jesús ; Navarro, Ricardo; Trujillo, Juan M.; Jorge, Elena
Palabras claveElenoside
Gastrointestinal motility
Small intestine preparation
Fecha de publicación28-nov-2006
EditorBaishideng Publishing Group
CitaciónWorld Journal of Gastroenterology 12(44): 7143-7148 (2006)
Resumen[Aim] To study the effects of elenoside, an arylnaph-thalene lignan from Justicia hyssopifolia, on gastro-intestinal motility in vivo and in vitro in rats.
[Methods] Routine in vivo experimental assessments were catharsis index, water percentage of boluses, intestinal transit, and codeine antagonism. The groups included were vehicle control (propylene glycol-ethanol-plant oil-tween 80), elenoside (i.p. 25 and 50 mg/kg), cisapride (i.p. 10 mg/kg), and codeine phosphate (intragastric route, 50 mg/kg). In vitro approaches used isolated rat intestinal tissues (duodenum, jejunum, and ileum). The effects of elenoside at concentrations of 3.2 multiply 10(-4), 6.4 multiply 10(-4) and 1.2 multiply 10(-3) mol/L, and cisapride at 10(-6) mol/L were investigated.
[Results] Elenoside in vivo produced an increase in the catharsis index and water percentage of boluses and in the percentage of distance traveled by a suspension of activated charcoal. Codeine phosphate antagonized the effect of 25 mg/kg of elenoside. In vitro, elenoside in duodenum, jejunum and ileum produced an initial decrease in the contraction force followed by an increase. Elenoside resulted in decreased intestinal frequency in duodenum, jejunum, and ileum. The in vitro and in vivo effects of elenoside were similar to those produced by cisapride.
[Conclusion] Elenoside is a lignan with an action similar to that of purgative and prokinetics drugs. Elenoside, could be an alternative to cisapride in treatment of gastrointestinal diseases as well as a preventive therapy for the undesirable gastrointestinal effects produced by opioids used for mild to moderate pain.
Descripción6 pages, 5 figures, 1 table.-- PMID: 17131476 [PubMed].
Versión del editorhttp://www.wjgnet.com/1007-9327/12/7143.asp
URIhttp://hdl.handle.net/10261/13462
ISSN1007-9327
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