Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/134576
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Marcos, I. S. | - |
dc.contributor.author | Basabe, Pilar | - |
dc.contributor.author | Mollinedo, Faustino | - |
dc.contributor.author | Padrón, José M. | - |
dc.date.accessioned | 2016-07-07T10:54:18Z | - |
dc.date.available | 2016-07-07T10:54:18Z | - |
dc.date.issued | 2014 | - |
dc.identifier | doi: 10.1016/j.ejmech.2013.12.012 | - |
dc.identifier | issn: 0223-5234 | - |
dc.identifier | e-issn: 1768-3254 | - |
dc.identifier.citation | European Journal of Medicinal Chemistry 73: 265-279 (2014) | - |
dc.identifier.uri | http://hdl.handle.net/10261/134576 | - |
dc.description.abstract | A series of indole sesquiterpenes analogues of polyalthenol and pentacyclindole have been synthesized starting from ent-halimic acid in order to test their biological activity. These analogues include diverse oxidation levels at the sesquiterpenyl moiety and different functionalization on the indole ring. All synthetic derivatives were tested against a representative panel of Gram positive and Gram negative bacterial strains, and the human solid tumour cell lines A549 (non-small cell lung), HBL-100 (breast), HeLa (cervix), SW1573 (non-small cell lung), T-47D (breast) and WiDr (colon). Overall, the compounds presented activity against the cancer cell lines. The resulting lead, displaying a polyalthenol scaffold, showed GI50 values in the range 1.2–5.7 μM against all cell lines tested. | - |
dc.description.sponsorship | This research was co-financed by the EU Research Potential (FP7-REGPOT-2012-CT2012-31637-IMBRAIN), the European Regional Development Fund (FEDER), the Spanish Red Temática de Investigación Cooperativa en Cáncer (RD06/0020/1037), the Spanish Instituto de Salud Carlos III (PI11/00840), and the Spanish Junta de Castilla y León (GR-178, SA063A07, GR-15, CSI052A11-2). I.C. acknowledges Junta de Castilla y León for a doctoral fellowship. | - |
dc.publisher | Elsevier | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/316137 | - |
dc.rights | closedAccess | - |
dc.subject | Antitumourals | - |
dc.subject | Ent-halimic acid | - |
dc.subject | Indole sesquiterpenes | - |
dc.subject | Pentacyclindole | - |
dc.subject | Polyalthenol | - |
dc.title | Synthesis and biological activity of polyalthenol and pentacyclindole analogues | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.ejmech.2013.12.012 | - |
dc.date.updated | 2016-07-07T10:54:18Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Red Temática de Investigación Cooperativa en Cáncer (España) | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Junta de Castilla y León | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100014180 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
11
checked on 11-abr-2024
WEB OF SCIENCETM
Citations
10
checked on 21-feb-2024
Page view(s)
191
checked on 23-abr-2024
Download(s)
84
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.