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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/134576
Título

Synthesis and biological activity of polyalthenol and pentacyclindole analogues

AutorMarcos, I. S.; Basabe, Pilar; Mollinedo, Faustino; Padrón, José M.
Palabras claveAntitumourals
Ent-halimic acid
Indole sesquiterpenes
Pentacyclindole
Polyalthenol
Fecha de publicación2014
EditorElsevier
CitaciónEuropean Journal of Medicinal Chemistry 73: 265-279 (2014)
ResumenA series of indole sesquiterpenes analogues of polyalthenol and pentacyclindole have been synthesized starting from ent-halimic acid in order to test their biological activity. These analogues include diverse oxidation levels at the sesquiterpenyl moiety and different functionalization on the indole ring. All synthetic derivatives were tested against a representative panel of Gram positive and Gram negative bacterial strains, and the human solid tumour cell lines A549 (non-small cell lung), HBL-100 (breast), HeLa (cervix), SW1573 (non-small cell lung), T-47D (breast) and WiDr (colon). Overall, the compounds presented activity against the cancer cell lines. The resulting lead, displaying a polyalthenol scaffold, showed GI50 values in the range 1.2–5.7 μM against all cell lines tested.
URIhttp://hdl.handle.net/10261/134576
DOI10.1016/j.ejmech.2013.12.012
Identificadoresdoi: 10.1016/j.ejmech.2013.12.012
issn: 0223-5234
e-issn: 1768-3254
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