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Synthesis and evaluation as antitumor agents of 1,4-naphthohydroquinone derivatives conjugated with amino acids and purines

AutorMolinari, Aurora; Castro, M. Ángeles; Mollinedo, Faustino
Palabras claveAntineoplastic
Hydroquinone–purine
Hydroquinone–amino acid
Hybrids
Cytotoxicity
Fecha de publicación2013
EditorWiley-VCH
CitaciónArchiv der Pharmazie 346(12): 882-890 (2013)
ResumenWe report on the synthesis of two series of 1,4-naphthohydroquinone derivatives conjugated with amino acids (Gly, Ala, Phe, and Glu) and with substituted purines linked by an aliphatic chain. The compounds were obtained through Diels-Alder cycloaddition between myrcene and 1,4-benzoquinone and evaluated in vitro for their cytotoxicity (GI50) against cultured human cancer cells of A-549 lung carcinoma, HT-29 colon adenocarcinoma, and MCF-7 breast carcinoma. The GI50 values found for some hydroquinone-amino acid and hydroquinone-purine hybrids against MCF-7 are in an activity range comparable to that of the reference drug doxorubicin.
URIhttp://hdl.handle.net/10261/134567
DOI10.1002/ardp.201300137
Identificadoresdoi: 10.1002/ardp.201300137
issn: 0365-6233
e-issn: 1521-4184
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