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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/13449
Título

The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers

AutorBriones, Carlos ; Stich, Michael ; Manrubia Cuevas, Susanna
Palabras claveRNA folding
Structural motif
Modular evolution
RNA ligation
Hairpin ribozyme
RNA polymerase
Fecha de publicaciónmay-2009
EditorCambridge University Press
CitaciónRNA 15(5): 743-749 (2009)
ResumenA main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on mineral surfaces. A number of computational studies have shown that the structural repertoire yielded by that process is dominated by topologically simple structures, notably hairpin-like ones. A fraction of these could display RNA ligase activity and catalyze the assembly of larger, eventually functional RNA molecules retaining their previous modular structure: molecular complexity increases but template replication is absent. This allows us to build up a stepwise model of ligation-based, modular evolution that could pave the way to the emergence of a ribozyme with RNA replicase activity, step at which information-driven Darwinian evolution would be triggered.
Descripción7 pages.-- PMID: 19318464 [PubMed].-- PMCID: PMC2673073 [Available Open Access on 2009/11/01].
Versión del editorhttp://dx.doi.org/10.1261/rna.1488609
URIhttp://hdl.handle.net/10261/13449
DOI10.1261/rna.1488609
ISSN1355-8382 (Print)
1469-9001 (Online)
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