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Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3-, CCL5- or CCL8-induced chemotaxis

AutorMoyano Cardaba, Clara; Mueller, Anja
Palabras claveJAK
Actin polymerization
Migration
Chemokine receptor
STAT
Fecha de publicación2013
EditorJohn Wiley & Sons
CitaciónCell Biochemistry and Function 31(4): 312-318 (2013)
ResumenChemokine receptors induce cell migration, but the molecular basis of the signal cascade involved is not completely understood. Therefore, we investigated here the molecular mechanisms of CCL3-, CCL5- and CCL8-induced cells migration and investigated whether the Janus kinase/signal transducer and activator of transcription (STAT) signalling pathway is involved. Some STAT3 inhibitors, like Cucurbitacin I, destroy the actin cytoskeleton inside the cells and therefore prevent any cellular migration. However, for inhibitors that do not affect the actin cytoskeleton or induce cell death, we show that chemokine-induced cell migration is not dependent on activation of Janus kinase 2 or STAT3.
URIhttp://hdl.handle.net/10261/134471
DOI10.1002/cbf.2901
Identificadoresdoi: 10.1002/cbf.2901
issn: 0263-6484
e-issn: 1099-0844
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