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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/134374
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dc.contributor.authorPaiva, Bruno-
dc.contributor.authorVidriales, Maria Belén-
dc.contributor.authorMartínez-López, Joaquín-
dc.contributor.authorMateos, Maria Victoria-
dc.contributor.authorOcio, Enrique M.-
dc.contributor.authorGutiérrez, Norma Carmen-
dc.contributor.authorDíaz-Mediavilla, J.-
dc.contributor.authorOrfao, Alberto-
dc.contributor.authorLahuerta, Juan José-
dc.contributor.authorBladé, Joan-
dc.contributor.authorSan Miguel, Jesús F.-
dc.date.accessioned2016-07-04T10:11:22Z-
dc.date.available2016-07-04T10:11:22Z-
dc.date.issued2013-
dc.identifierdoi: 10.1038/leu.2013.166-
dc.identifierissn: 0887-6924-
dc.identifiere-issn: 1476-5551-
dc.identifier.citationLeukemia 27(10): 2056-2061 (2013)-
dc.identifier.urihttp://hdl.handle.net/10261/134374-
dc.descriptionGEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study group: et al.-
dc.description.abstractAchieving complete remission (CR) in multiple myeloma (MM) translates into extended survival, but two subgroups of patients fall outside this paradigm: cases with unsustained CR, and patients that do not achieve CR but return into a monoclonal gammopathy of undetermined significance (MGUS)-like status with long-term survival. Here, we describe a novel automated flow cytometric classification focused on the analysis of the plasma-cell compartment to identify among newly diagnosed symptomatic MM patients (N=698) cases with a baseline MGUS-like profile, by comparing them to MGUS (N=497) patients and validating the classification model in 114 smoldering MM patients. Overall, 59 symptomatic MM patients (8%) showed an MGUS-like profile. Despite achieving similar CR rates after high-dose therapy/autologous stem cell transplantation vs other MM patients, MGUS-like cases had unprecedented longer time-to-progression (TTP) and overall survival (OS; ∼60% at 10 years; P<0.001). Importantly, MGUS-like MM patients failing to achieve CR showed similar TTP (P=0.81) and OS (P=0.24) vs cases attaining CR. This automated classification also identified MGUS patients with shorter TTP (P=0.001, hazard ratio: 5.53) and ultra-high-risk smoldering MM (median TTP, 15 months). In summary, we have developed a biomarker that identifies a subset of symptomatic MM patients with an occult MGUS-like signature and an excellent outcome, independently of the depth of response.-
dc.publisherNature Publishing Group-
dc.rightsclosedAccess-
dc.titleA multiparameter flow cytometry immunophenotypic algorithm for the identification of newly diagnosed symptomatic myeloma with an MGUS-like signature and long-term disease control-
dc.typeartículo-
dc.identifier.doi10.1038/leu.2013.166-
dc.date.updated2016-07-04T10:11:22Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.relation.csicSí-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairetypeartículo-
item.grantfulltextnone-
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