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Antitumor activity of new enantiopure pybox-ruthenium complexes

AuthorsGamasa, M. Pilar; Mollinedo, Faustino ; Lastra, Elena
Issue Date2013
PublisherRoyal Society of Chemistry (Great Britain)
CitationDalton Transactions 42(38): 13955-13967 (2013)
AbstractNew ruthenium complexes containing enantiopure 2,6-bis[4′(R)- phenyloxazolin-2′-il-pyridine] ((R,R)-Ph-pybox), 2,6-bis[4′(S)- isopropyloxazolin-2′-il-pyridine] ((S,S)-iPr-pybox) or 2,6-bis[4′(R)-isopropyloxazolin-2′-il-pyridine] ((R,R)- iPr-pybox) and water soluble 1,3,5-triaza-7-phosphaadamantane (PTA) or N-substituted PTA phosphanes have been synthesized in high yields and fully characterized. The interactions of these compounds with plasmidic DNA and their cytotoxic activity against the human cervical cancer HeLa cell line are reported, pointing out for the first time the different behaviour of ruthenium enantiomers affecting the cell cycle in HeLa tumor cells.
Identifiersdoi: 10.1039/C3DT51160J
issn: 1477-9226
e-issn: 1477-9234
Appears in Collections:(IBMCC) Artículos
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