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Title

Biomimetic synthesis of an antitumour indole sesquiterpene alkaloid, 12-epi-ent-pentacyclindole

AuthorsMarcos, I. S.; Basabe, Pilar; Mollinedo, Faustino ; Urones, Julio G.
KeywordsPentacyclindole
ent-Halimic acid
Indole sesquiterpenes
Polyalthenol
Antitumour
Issue Date2013
PublisherElsevier
CitationTetrahedron 69835): 7285-7289 (2013)
AbstractBiomimetic synthesis of 12-epi-ent-pentacyclindole 7, using as key step the cyclization of 12-epi-ent-polyalthenol acetate has been carried out. This way, the structure and absolute configuration of the natural product pentacyclindole 1 has been confirmed. The synthesized indole sesquiterpenes 7, 11 and 12 show cellular proliferation inhibition of a number of human leukaemic and solid tumour cell lines.
URIhttp://hdl.handle.net/10261/134368
DOI10.1016/j.tet.2013.06.075
Identifiersdoi: 10.1016/j.tet.2013.06.075
issn: 0040-4020
Appears in Collections:(IBMCC) Artículos
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