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dc.contributor.authorGonzález-Herrero, Inés-
dc.contributor.authorRomero-Camarero, Isabel-
dc.contributor.authorCañueto, Javier-
dc.contributor.authorPérez-Losada, J.-
dc.contributor.authorSánchez García, Isidro-
dc.contributor.authorRomán-Curto, Concépción-
dc.date.accessioned2016-07-04T09:29:28Z-
dc.date.available2016-07-04T09:29:28Z-
dc.date.issued2013-
dc.identifierdoi: 10.1111/bjd.12428-
dc.identifierissn: 0007-0963-
dc.identifiere-issn: 1365-2133-
dc.identifier.citationBritish Journal of Dermatology 169(4): 830-837 (2013)-
dc.identifier.urihttp://hdl.handle.net/10261/134367-
dc.description.abstract[Background]: Melanoma is responsible for almost 80% of the deaths attributed to skin cancer. Stem cells, defined by CD133 expression, have been implicated in melanoma tumour growth, but their specific role is still uncertain. [Objectives]: We hypothesized that the phenotypic heterogeneity of human cutaneous melanomas is related to their content of CD133+ cells. [Methods]: We compared the percentages of CD133+ cells in 29 tumours from four classic types of melanoma: lentigo maligna melanoma (LMM), superficial spreading melanoma, nodular melanoma and acral lentiginous melanoma (ALM). Also, we compared the percentages of CD133+ cells in melanomas with different degrees of exposure to ultraviolet radiation: 16 melanomas from skin with chronic sun-induced damage and 13 melanomas from skin without such damage. [Results]: We found a statistically significant increase of CD133+ cells in three different contexts: in melanomas arising on skin with signs of chronic sun-induced damage vs. nonexposed skin, in melanomas in situ vs. invasive melanomas, and in LMM vs. ALM. The proportions of CD133+ cells did not differ among samples of normal skin with different degrees of sun exposure. A distinct subpopulation of CD133+CXCR4+ cancer stem cells (CSCs) was identified and shown to be related to the invasive phenotype of the tumours. [Conclusions]: Here, we provide evidence showing, for the first time, that an increase in the CD133+ cell content is associated both with melanomas arising on skin with signs of chronic sun-induced damage and in melanomas in situ with better prognosis. Moreover, our study further confirms the existence of a subpopulation of CD133+CXCR4+ CSCs in cutaneous melanomas with invasive phenotype and poor prognosis. What's already known about this topic? Stem cells, defined by CD133 expression, have been implicated in melanoma tumour growth, but their specific role is still uncertain. What does this study add? In the present study, we provide evidence showing, for the first time, that an increase in the content of CD133+ cells is associated with melanomas arising on skin with signs of chronic sun-induced damage and in melanomas in situ with better prognosis. This study also confirms the existence of a subpopulation of CD133+CXCR4+ cancer stem cells in melanomas with invasive phenotype and poor prognosis.-
dc.description.sponsorshipResearch in the ISG group is partially supported by FEDER and by MICINN SAF2012-32810, by MEC OncoBIO Consolider-Ingenio 2010 (Ref. CSD2007-0017), by an NIH grant (R01 CA109335-04A1), the ARIMMORA project (FP7-ENV-2011, European Union Seventh Framework Programme) and by proyecto en red de investigación en celulas madre tumorales supported by Obra Social Kutxa y Conserjería de Sanidad de la Junta de Castilla y Leon. All Spanish funding is cosponsored by the European Union FEDER programme. ISG is an API lab of the EuroSyStem project.-
dc.publisherBlackwell Publishing-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/282891-
dc.rightsclosedAccess-
dc.titleCD133+ cell content correlates with tumour growth in melanomas from skin with chronic sun-induced damage-
dc.typeArtículo-
dc.identifier.doi10.1111/bjd.12428-
dc.date.updated2016-07-04T09:29:28Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderEuropean Commission-
dc.contributor.funderNational Institutes of Health (US)-
dc.contributor.funderObra Social Kutxa-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderJunta de Castilla y León-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
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