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http://hdl.handle.net/10261/13429
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Aguirre, Jacobo | en_US |
dc.contributor.author | Manrubia Cuevas, Susanna | en_US |
dc.date.accessioned | 2009-06-03T05:58:01Z | - |
dc.date.available | 2009-06-03T05:58:01Z | - |
dc.date.issued | 2007-01-22 | en_US |
dc.identifier.citation | EPL 77(3): 38001 (2007) | en_US |
dc.identifier.issn | 1286-4854 | - |
dc.identifier.uri | http://hdl.handle.net/10261/13429 | - |
dc.description | 6 pages, 4 figures.-- PACS nrs.: 87.10.+e; 87.23.Kg; 89.90.+n.-- ISI Article Identifier: 000245743000025.-- Printed version published Feb 2007. | en_US |
dc.description.abstract | The composition of a quasispecies is completely characterized, in the large population and long time limit, by the matrix yielding the transition probabilities between different types in the population. Further, its asymptotic growth rate —i.e. the largest eigenvalue of the transition matrix— completely determines the winning population in an equilibrium competition. However, due to the intrinsically heterogeneous nature of quasispecies, out-of-equilibrium fluctuations in population size might change the expected fate of competition experiments. Using a simple model for a heterogeneous population we quantify the probability that, after a population bottleneck, the a priori weaker competitor wins in a competition with a population characterized by a larger asymptotic growth rate. We analyse the role played by different degrees of neutrality in the outcome of the process, and demonstrate that lower neutrality favours the weaker competitor in out-of-equilibrium situations. Our results might shed light on empirical observations in competition experiments with RNA viruses. | - |
dc.description.sponsorship | The authors acknowledge the support of Spanish MEC (project FIS2004-06414). SCM benefits from a Ramón y Cajal contract. | - |
dc.format.extent | 2373 bytes | - |
dc.format.mimetype | text/plain | - |
dc.publisher | EDP Sciences | - |
dc.publisher | Institute of Physics Publishing | - |
dc.publisher | Società Italiana di Fisica | - |
dc.rights | closedAccess | en_US |
dc.subject | [PACS] Biological and medical physics: General theory and mathematical aspects | - |
dc.subject | [PACS] Dynamics of evolution | - |
dc.subject | [PACS] Other topics in areas of applied and interdisciplinary physics | - |
dc.title | Out-of-equilibrium competitive dynamics of quasispecies | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1209/0295-5075/77/38001 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1209/0295-5075/77/38001 | - |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
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