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Detection of anti-heat shock protein 90 β (Hsp90β) antibodies in cerebrospinal fluid

AuthorsCid, Cristina ; García-Villanueva, M.; Salinas, Matilde; Alcázar, Alberto
Cell membrane
Cerebrospinal fluid
Multiple sclerosis
Western blot
Issue Date10-Jan-2007
CitationJournal of Immunological Methods 318(1-2): 153-157 (2007)
AbstractAntibodies against heat shock protein 90β (Hsp90β) recognize the antigen on the cell surface of the oligodendrocyte precursor cells and cause a decrease of oligodendrocyte population in cell cultures. These antibodies have been found in patients with multiple sclerosis (MS). This report describes an original and sensitive method to detect anti-Hsp90β antibodies in cerebrospinal fluid (CSF) using a western blot procedure. We have developed the method for autoantibody detection using Hsp90β from cell membrane fraction instead of commercial Hsp90β as antigen. The presence of anti-Hsp90β antibodies in CSF of MS patients may play a pathogenic role in MS, and a large-scale study is needed to establish a possible diagnostic value of these antibodies in MS patients.
Description5 pages, 3 figures.-- PMID: 17112536 [PubMed].-- ISI Article Identifier: 000243858800017.-- Available online Oct 18, 2006.
Publisher version (URL)http://dx.doi.org/10.1016/j.jim.2006.09.017
Appears in Collections:(CAB) Artículos
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