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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/134217
Título

Prognostic value of telomere length in acute coronary syndrome

AutorPérez-Rivera, José Ángel; Pabón-Osuna, Pedro; Cieza-Borrella, Clara; Martín-Herrero, Francisco; González-Porras, José R.; González-Sarmiento, Rogelio
Palabras claveCardiovascular prognosis
Cellular ageing
Acute coronary syndrome
Telomerase polymorphisms
Telomere length
Fecha de publicación2012
EditorElsevier
CitaciónMechanisms of Ageing and Development 133(11-12): 695-697 (2012)
ResumenTelomere and telomerase are involved in cellular and organismal ageing and have been related to human diseases. Coronary artery disease is one of the most common age-related health problems in developed countries. Nevertheless, the specific role of cellular ageing in this process is still unclear. In this study, we analyze the possible prognostic value of telomere length and telomerase polymorphisms in a population of 150 middle aged males (mean age 62 ± 7) admitted for acute coronary syndrome who were followed up for more than 600 days. Peripheral blood samples were obtained and relative and comparative qPCR was used to measure telomere length and real time PCR to study the polymorphisms. Two prognostic combined events were defined. Long telomere length was revealed as an independent predictor (protector) of combined event presentation during long term follow up in our patients.
URIhttp://hdl.handle.net/10261/134217
DOI10.1016/j.mad.2012.09.003
Identificadoresdoi: 10.1016/j.mad.2012.09.003
issn: 0047-6374
e-issn: 1872-6216
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