Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/134167
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Córdoba, Iris | - |
dc.contributor.author | Chillón, M. del Carmen | - |
dc.contributor.author | Sarasquete, María Eugenia | - |
dc.contributor.author | Martin-Herrero, Francisco | - |
dc.contributor.author | Guerrero Arroyo, María del Carmen | - |
dc.contributor.author | Lozano, Francisco S. | - |
dc.contributor.author | González, Marcos | - |
dc.contributor.author | González-Porras, José R. | - |
dc.date.accessioned | 2016-06-28T12:01:08Z | - |
dc.date.available | 2016-06-28T12:01:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier | doi: 10.1111/j.1600-0609.2012.01809.x | - |
dc.identifier | issn: 0902-4441 | - |
dc.identifier | e-issn: 1600-0609 | - |
dc.identifier.citation | European Journal of Haematology 89(3): 250-255 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/134167 | - |
dc.description | et al. | - |
dc.description.abstract | [Background]: Few studies have evaluated the risk of pregnancy-related adverse events in asymptomatic relatives of probands for VTE and factor V Leiden or the G20210A variant. The antepartum management of this population ranges from antepartum anticoagulation therapy to clinical surveillance. [Objective]: To evaluate the risk of placenta-mediated pregnancy complications and pregnancy-related VTE in VTE-asymptomatic families of probands with VTE and who are heterozygous carriers of either factor V Leiden or PT-G20210A mutation. [Methods]: One hundred and fifty-eight relatives, who had 415 pregnancies, were retrospectively evaluated. Odds ratios and 95% confidence intervals were calculated to compare pregnancy outcomes between women with and without thrombophilia. [Results]: In the factor V Leiden group, 22 placenta-mediated pregnancy events of 152 pregnancies (14.4%) were reported, compared with 25 adverse events of 172 pregnancies in the G20210A prothrombin group (14.5%) and 13 adverse events of 91 pregnancies in the non-carrier group (14.2%). Carriers of factor V Leiden or G20210A prothrombin were not associated with a higher risk of pregnancy-adverse outcomes compared with non-carriers: OR 1.02 (95% CI, 0.40-2.25) and 1.25 (95% CI, 0.48-3.24), respectively. Four episodes of pregnancy-associated VTE of 415 pregnancies (0.96%) were recorded. Two episodes of VTE in the G20210A group, one in the factor V Leiden group, and one episode in the non-carrier group were noted. [Conclusions]: In VTE-asymptomatic relatives of probands with VTE, the presence of factor V Leiden or the G20210A prothrombin mutation in heterozygosis should not lead to a decision to instigate antepartum prophylaxis. | - |
dc.publisher | John Wiley & Sons | - |
dc.relation.isversionof | Preprint | - |
dc.rights | openAccess | - |
dc.title | Risk of placenta-mediated pregnancy complications or pregnancy-related VTE in VTE-asymptomatic families of probands with VTE and heterozygosity for factor V Leiden or G20210 prothrombin mutation | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1111/j.1600-0609.2012.01809.x | - |
dc.relation.publisherversion | http://dx.doi.org/10.1111/j.1600-0609.2012.01809.x | - |
dc.date.updated | 2016-06-28T12:01:08Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.relation.csic | Sí | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Leiden G20210.pdf | 143,42 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
3
checked on 21-mar-2024
WEB OF SCIENCETM
Citations
4
checked on 29-feb-2024
Page view(s)
261
checked on 28-mar-2024
Download(s)
303
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.