English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/134167
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Risk of placenta-mediated pregnancy complications or pregnancy-related VTE in VTE-asymptomatic families of probands with VTE and heterozygosity for factor V Leiden or G20210 prothrombin mutation

AuthorsCórdoba, Iris; Chillón, M. del Carmen; Sarasquete, María Eugenia; Martin-Herrero, Francisco; Guerrero Arroyo, María del Carmen ; Lozano, Francisco S.; González, Marcos ; González-Porras, José R.
Issue Date2012
PublisherJohn Wiley & Sons
CitationEuropean Journal of Haematology 89(3): 250-255 (2012)
Abstract[Background]: Few studies have evaluated the risk of pregnancy-related adverse events in asymptomatic relatives of probands for VTE and factor V Leiden or the G20210A variant. The antepartum management of this population ranges from antepartum anticoagulation therapy to clinical surveillance. [Objective]: To evaluate the risk of placenta-mediated pregnancy complications and pregnancy-related VTE in VTE-asymptomatic families of probands with VTE and who are heterozygous carriers of either factor V Leiden or PT-G20210A mutation. [Methods]: One hundred and fifty-eight relatives, who had 415 pregnancies, were retrospectively evaluated. Odds ratios and 95% confidence intervals were calculated to compare pregnancy outcomes between women with and without thrombophilia. [Results]: In the factor V Leiden group, 22 placenta-mediated pregnancy events of 152 pregnancies (14.4%) were reported, compared with 25 adverse events of 172 pregnancies in the G20210A prothrombin group (14.5%) and 13 adverse events of 91 pregnancies in the non-carrier group (14.2%). Carriers of factor V Leiden or G20210A prothrombin were not associated with a higher risk of pregnancy-adverse outcomes compared with non-carriers: OR 1.02 (95% CI, 0.40-2.25) and 1.25 (95% CI, 0.48-3.24), respectively. Four episodes of pregnancy-associated VTE of 415 pregnancies (0.96%) were recorded. Two episodes of VTE in the G20210A group, one in the factor V Leiden group, and one episode in the non-carrier group were noted. [Conclusions]: In VTE-asymptomatic relatives of probands with VTE, the presence of factor V Leiden or the G20210A prothrombin mutation in heterozygosis should not lead to a decision to instigate antepartum prophylaxis.
Descriptionet al.
Publisher version (URL)http://dx.doi.org/10.1111/j.1600-0609.2012.01809.x
URIhttp://hdl.handle.net/10261/134167
DOI10.1111/j.1600-0609.2012.01809.x
Identifiersdoi: 10.1111/j.1600-0609.2012.01809.x
issn: 0902-4441
e-issn: 1600-0609
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
Leiden G20210.pdf143,42 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.